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The Relationship of Pathogenic mtDNA Somatic Mutations with Platinum Resistance and Relapse of HGSOC
| No. of Patients (%) |
No. of Platinum- Resistant/Relapsed Patients (%) | p-value | |
|---|---|---|---|
| Carry pathogenic heteroplasmic mtDNA somatic mutations | 10 (100) | 8 (80.0) | 0.035* |
| DO NOT carry any pathogenic mtDNA somatic mutations | 6 (100) | 1 (16.7) |
Note: *By Fisher exact test. Bold, p-values less than 0.05.
Abbreviations: HGSOC, high-grade serous adenocarcinoma; mt, mitochondrial.
