Table 4.

Univariate and Multivariable Analysis on Survival of Patients with Breast Cancer

Characteristics	RFS				OS
	Univariate		Multivariate		Univariate		Multivariate
	HR (95% CI)	P	aHR (95% CI)	P	HR (95% CI)	P	aHR (95% CI)	P
Age		0.098		0.117		0.226		0.154
≤55	1.00		1.00		1.00		1.00
>55	1.74 (0.90–3.34)		2.31 (0.98–4.96)		1.53 (0.77–3.07)		1.82 (0.80–4.13)
T stage		<0.001		0.292		<0.001		0.582
T1/T2	1.00		1.00		1.00		1.00
T3/T4	5.08 (2.38–10.9)		2.01 (0.55–7.40)		5.26 (2.43–11.4)		1.43 (0.40–5.17)
N stage		<0.001		0.001		<0.001		<0.001
N0/N1	1.00		1.00		1.00		1.00
N2/N3	3.32 (1.70–6.45)		1.70 (1.24–2.33)		4.15 (2.07–8.32)		1.81 (1.30–2.52)
Clinical stage		<0.001		0.567		<0.001		0.286
I/II	1.00		1.00		1.00		1.00
III/IV	4.96 (2.56–9.61)		1.62 (0.31–8.50)		6.53 (3.18–13.4)		2.44 (0.47–12.58)
Grade		0.290		0.381		0.927		0.797
I/II	1.00		1.00		1.00		1.00
III	1.48 (0.72–3.08)		1.47 (0.62–3.44)		1.04 (0.45–2.41)		0.88 (0.34–2.31)
MTFR2		<0.001		0.005		0.001		0.017
Low	1.00		1.00		1.00		1.00
High	4.29 (1.96–9.43)		3.85 (1.52–9.77)		4.39 (1.90–10.1)		3.30 (1.23–8.82)
ER		0.994		0.675		0.903		0.821
Negative	1.00		1.00		1.00		1.00
Positive	0.99 (0.51–1.97)		1.37 (0.32–5.93)		0.96 (0.47–1.96)		1.18 (0.28–5.06)
PR		0.807		0.142		0.988		0.259
Negative	1.00		1.00		1.00		1.00
Positive	1.09 (0.56–2.11)		3.42 (0.66–17.6)		1.01 (0.50–2.02)		2.54 (0.50–12.8)
HER2		0.001		0.001		<0.001		0.001
Negative	1.00		1.00		1.00		1.00
Positive	2.91 (1.51–5.62)		4.81 (1.84–12.6)		3.66 (1.83–7.31)		5.02 (1.91–13.2)
Group		0.897		0.223		0.854		0.972
non-TNBC	1.00		1.00		1.00		1.00
TNBC	1.06 (0.41–2.74)		1.08 (0.73–3.86)		0.91 (0.32–2.58)		1.02 (0.40–2.59)
Radiotherapy		0.619		0.122		0.962		0.206
No	1.00		1.00		1.00		1.00
Yes	0.83 (0.40–1.72)		0.52 (0.23–1.19)		0.98 (0.47–2.07)		0.57 (0.24–1.36)
Chemotherapy		0.548		0.501		0.692		0.767
No	1.00		1.00		1.00		1.00
Yes	0.81 (0.40–1.62)		1.32 (0.58–3.00)		0.86 (0.41–1.82)		1.15 (0.47–2.82)

Abbreviation: aHR, adjusted with the variables listed in this table.