Table 3.

Sensitivity Analysis by Adding Anti-Inflammatory Medication as Covariate for Predicting CV Events in 302 Patients with CKD by Multivariate Cox Regression Analysis

Serum IL-4 Levels	Model 1	Model 2	Model 3
Quartile 1 (low)	1.000 (ref.)	1.000 (ref.)	1.000 (ref.)
Quartile 2	1.201 (1.012–1.565)	1.130 (1.008–1.523)	1.071 (1.001–1.395)
Quartile 3	1.284 (1.113–1.727)	1.254 (1.100–1.702)	1.244 (1.072–1.631)
Quartile 4 (high)	1.820 (1.246–2.294)	1.742 (1.210–2.136)	1.547 (1.196–2.056)
P-trend	<0.001	0.002	0.007

Notes: Model 1: Adjusted for age, gender and anti-inflammatory medication. Model 2: Adjusted for age, gender, BMI, current smoker, current drinker, admission SBP and DBP, hyperlipidemia, dialysis history, causes of CKD and anti-inflammatory medication. Model 3: Adjusted for age, gender, BMI, current smoker, current drinker, admission DBP and DBP, hyperlipidemia, dialysis history, causes of CKD, laboratory measurements and anti-inflammatory medication.

Abbreviations: CKD, chronic kidney disease; CV, cardiovascular; IL-4, interleukin-4; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure.