Table 1.
List of 44 APOBEC-associated hotspot mutations and their frequencies in bladder cancer (n = 602)
| Gene mutation | N. of mutated samples |
|---|---|
| FGFR3 S249C | 51 |
| PIK3CA E545K | 47 |
| ERBB2 S310F | 27 |
| PIK3CA E542K | 25 |
| RXRA S427F | 19 |
| TP53 E285K | 17 |
| TP53 R280T | 15 |
| KDM6A Q555* | 11 |
| TBC1D12 *1* | 11 |
| C3orf70 S6L | 10 |
| RHOB E172K | 9 |
| AHR Q383H | 8 |
| LPAR6 F316F | 8 |
| TP53 Q331* | 8 |
| TP53 E271K | 8 |
| RARS2 R6C | 7 |
| SF3B1 E902K | 7 |
| TP53 R280K | 7 |
| ERBB3 E332K | 6 |
| MROH2B E1109K | 6 |
| PIK3CA E545Q | 6 |
| PPCS S113L | 6 |
| STAG2 Q593* | 6 |
| ACSS3 S290L | 5 |
| CELSR3 E356K | 5 |
| KCNF1 E158K | 5 |
| PDE3A L275L | 5 |
| PIK3CA E726K | 5 |
| PLXNA2 E1480K | 5 |
| RHOB E47K | 5 |
| TFPI2 R222C | 5 |
| TP53 K132N | 5 |
| CAMK2G I132I | 4 |
| CELSR1 E1382K | 4 |
| EP300 Q1082* | 4 |
| ERBB4 E317K | 4 |
| FAM90A1 L251L | 4 |
| FURIN R693W | 4 |
| KDM6A S1061* | 4 |
| PBX2 E70K | 4 |
| RB1 Q217* | 4 |
| RREB1 Q392* | 4 |
| TP53 Q192* | 4 |
| TTC23L Q263Q | 4 |