Table 3.

Multivariable Analysis in Elderly Patients with iCCA

	Cox Regression Analysis			Fine-Gray Regression Analysis
Variables	HR	95% CI	P value	HR	95% CI	P value
Age (≥70 vs <70 years)	1.706	1.101–2.645	0.017	1.176	0.687–2.013	0.560
Sex (female vs male)	0.959	0.673–1.367	0.817	0.781	0.520–1.173	0.230
CA19-9 (>29.5 vs ≤29.5 U/mL)	1.332	0.941–1.886	0.106	1.283	0.875–1.862	0.210
Maximum tumor size (>5 vs ≤5cm)	0.982	0.685–1.408	0.982	1.082	0.711–1.643	0.720
Tumor number (multiple vs single)	1.314	0.902–1.914	0.154	1.232	0.797–1.912	0.340
Tumor encapsulation (incomplete vs complete)	1.188	0.830–1.702	0.346
MVI (presence vs absence)	1.699	1.093–2.641	0.019	1.843	1.138–2.962	0.013
Macroscopic vascular invasion (presence vs absence)	2.398	1.648–3.489	<0.001	2.405	1.602–3.591	<0.001
Satellite nodules (yes vs no)				1.463	0.901–2.384	0.120
Lymph node metastasis (yes vs no)	4.059	2.733–6.028	<0.001	1.796	1.141–2.823	0.011

Note: Bold indicates statistically significant difference.

Abbreviations: HBsAg, hepatitis B surface antigen; CA19-9, carbohydrate antigen 19–9; MVI, microvascular invasion; LLR, laparoscopic liver resection; OLR, open liver resection.