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Inhibition of the NS2B-NS3 interactions and protease activity. (A) Chemical structure of MB. (B) Dose-dependent inhibition of SLC upon binding of NLuc-NS2B49-66 to GST-CLuc-NS3 of DENV2 by MB. N = 3. (C) Dose-response inhibitions of the DENV2 His-NS2B/His-MBP-NS3 protease activity by MB. N = 3. (D) Cell viability assay. A549 cells were incubated with various concentrations of MB and then assayed for viability at 48-hr post-incubation. N = 3.
