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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Eur J Med Chem. 2020 Jan 2;189:112023. doi: 10.1016/j.ejmech.2019.112023

Figure 7. Cellular activity of compound 25.

Figure 7.

(A) 25 showing time- and dose-dependent killing of murine cell lines transformed with MLL-AF9 and (B) doesn’t show any effect on the growth of E2A-HLF cells, as EPZ004777, reported DOT1L inhibitor. (C) 25 inhibits cellular H3K79 dimethylation in MLL-AF9 murine model cells. (D) Wright-Giemsa stain of cells after treatment with 25 at various doses and EPZ00477 at 3 μM inducing cell differentiation (Olympus IX83 Inverted Microscope; Original magnification x400).