Table 2:
D3: TCGA (LUSC) |
D3: TCGA (LUAD) |
D4: University of Bern (LUSC) |
||||
---|---|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
Univariable Cox model analysis for overall survival | ||||||
Age: >65 years vs ≤65 years | 1·13 (0·81–1·57) | 0·488 | 1·00 (0·72–1·41) | 0·982 | 1·71 (0·84–3·50) | 0·139 |
Sex: male vs female | 0·81 (0·58–1·13) | 0·219 | 1·30 (0·92–1·86) | 0·142 | 3·62 (1·30–10·12) | 0·014 |
Race: white vs other | 1·60 (0·93–2·74) | 0·087 | 0·81 (0·53–1·24) | 0·326 | NA | NA |
Smoking status: ever vs never | 1·29 (0·79–2·10) | 0·303 | 1·36 (0·79–2·34) | 0·266 | NA | NA |
T stage: T2/T2a/T2b/T3 vs T1/T1a/T1b | 1·24 (0·88–1·74) | 0·213 | 1·22 (0·86–1·72)) | 0·273 | 1·26 (0·60–2·61) | 0·542 |
N stage: N1 vs N0 | 1·35 (0·90–2·01) | 0·146 | 1·92 (1·18–3·13) | 0·0083 | 1·19 (0·60–2·35) | 0·614 |
Overall stage: II vs I | 1·22 (0·86–1·73) | 0·259 | 1·25 (0·85–1·84) | 0·257 | 1·05 (0·59–1·85) | 0·867 |
Image model: high risk vs low risk | 1·48 (1·06–2·08) | 0·022 | 1·62 (1·15–2·30) | 0·006 | 2·24 (1·04–4·80) | 0·039 |
Multivariable Cox model analysis controlling for clinical and pathological variables | ||||||
Age: >65 years vs ≤65 years | 1·14 (0·81–1·61) | 0·451 | 1·12 (0·78–1·60) | 0·540 | 1·80 (0·84–3·85) | 0·131 |
Smoking status: ever vs never | 1·36 (0·83–2·23) | 0·221 | 1·14 (0·64–2·01) | 0·661 | NA | NA |
Overall stage: II vs I | 1·13 (0·66–1·94) | 0·651 | 1·86 (1·04–3·32) | 0·037 | 1·13 (0·66–1·94) | 0·708 |
T stage: T2/T2a/T2b/T3 vs T1/T1a/T1b | 1·26 (0·85–1·87) | 0·244 | 1·25 (0·85–1·85) | 0·263 | 1·39 (0·60–3·19) | 0·438 |
N stage: N1 vs N0 | 1·36 (0·77–2·41) | 0·292 | 3·11 (1·55–6·23) | 0·0012 | 1·17 (0·52–2·65) | 0–709 |
Image model: high risk vs low risk | 1·52 (1·08–2·13) | 0·016 | 1·55 (1·09–2·22) | 0·015 | 2·34 (1·07–5·14) | 0·034 |
Mantel-Haenszel HRs are provided. TCGA=The Cancer Genome Atlas. LUSC=lung squamous cell carcinoma. LUAD=lung adenocarcinoma. HR=hazard ratio. NA=not applicable.