. Author manuscript; available in PMC: 2020 Nov 6.

Published in final edited form as: Lancet Digit Health. 2020 Oct 19;2(11):e594–e606. doi: 10.1016/s2589-7500(20)30225-9

Table 2:

Univariable and multivariable analysis for 5-year overall survival on the validation test sets D₃ and D₄

	D₃: TCGA (LUSC)		D₃: TCGA (LUAD)		D₄: University of Bern (LUSC)
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Univariable Cox model analysis for overall survival
Age: >65 years vs ≤65 years	1·13 (0·81–1·57)	0·488	1·00 (0·72–1·41)	0·982	1·71 (0·84–3·50)	0·139
Sex: male vs female	0·81 (0·58–1·13)	0·219	1·30 (0·92–1·86)	0·142	3·62 (1·30–10·12)	0·014
Race: white vs other	1·60 (0·93–2·74)	0·087	0·81 (0·53–1·24)	0·326	NA	NA
Smoking status: ever vs never	1·29 (0·79–2·10)	0·303	1·36 (0·79–2·34)	0·266	NA	NA
T stage: T2/T2a/T2b/T3 vs T1/T1a/T1b	1·24 (0·88–1·74)	0·213	1·22 (0·86–1·72))	0·273	1·26 (0·60–2·61)	0·542
N stage: N1 vs N0	1·35 (0·90–2·01)	0·146	1·92 (1·18–3·13)	0·0083	1·19 (0·60–2·35)	0·614
Overall stage: II vs I	1·22 (0·86–1·73)	0·259	1·25 (0·85–1·84)	0·257	1·05 (0·59–1·85)	0·867
Image model: high risk vs low risk	1·48 (1·06–2·08)	0·022	1·62 (1·15–2·30)	0·006	2·24 (1·04–4·80)	0·039
Multivariable Cox model analysis controlling for clinical and pathological variables
Age: >65 years vs ≤65 years	1·14 (0·81–1·61)	0·451	1·12 (0·78–1·60)	0·540	1·80 (0·84–3·85)	0·131
Smoking status: ever vs never	1·36 (0·83–2·23)	0·221	1·14 (0·64–2·01)	0·661	NA	NA
Overall stage: II vs I	1·13 (0·66–1·94)	0·651	1·86 (1·04–3·32)	0·037	1·13 (0·66–1·94)	0·708
T stage: T2/T2a/T2b/T3 vs T1/T1a/T1b	1·26 (0·85–1·87)	0·244	1·25 (0·85–1·85)	0·263	1·39 (0·60–3·19)	0·438
N stage: N1 vs N0	1·36 (0·77–2·41)	0·292	3·11 (1·55–6·23)	0·0012	1·17 (0·52–2·65)	0–709
Image model: high risk vs low risk	1·52 (1·08–2·13)	0·016	1·55 (1·09–2·22)	0·015	2·34 (1·07–5·14)	0·034

Mantel-Haenszel HRs are provided. TCGA=The Cancer Genome Atlas. LUSC=lung squamous cell carcinoma. LUAD=lung adenocarcinoma. HR=hazard ratio. NA=not applicable.