Table 1.

Composite measures of disease activity used in rheumatoid arthritis

Component	Clinical Disease Activity Index	Disease activity score (28 joints) (with four variables)
Number of swollen joints	0–28 Simple sum	Square root of the simple sum
Number of painful joints	0–28 Simple sum	Square root of the simple sum
Acute-phase reagents	–	Erythrocyte sedimentation rate 2–100 mm or C-reactive protein 0.1–10 mg/dL logarithmic transformation
Global health assessment (patient)	–	0–100 mm
Assessment of disease activity (patient)	0–10 cm	–
Assessment of disease activity (examiner)	0–10 cm	–
Total index	Simple sum	Calculation formula (requires a calculator)
Index variation	0–76	0.49–9.07

Modified Mota et al.²⁰