Table 3.
Association of explanatory parameters with elevated peak ALT in induced blood-stage malaria
| Explanatory parameter | Peak ALT | Logistic regression | Logistic regression with fixed cohort effect | |||
|---|---|---|---|---|---|---|
| < 2.5 × ULN (n = 21) | ≥ 2.5 × ULN (n = 11) | OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Median parasite clearance half-life (hours), (IQR) | 4.70 (4.12–5.69) | 4.36 (3.16–5.40) | 0.69 (0.34–1.39) | 0.30 | 1.06 (0.43–2.60) | 0.90 |
| Median peak parasitemia (parasites/mL), (IQR) | 45,156 (12,922–78,227) | 96,020 (52,370–201,433) | 3.72 (0.77–18.03) | 0.10 | 1.78 (0.17–18.72) | 0.63 |
| Median parasite clearance burden (IQR) | 0.96 (0.71–1.41) | 2.06 (1.15–2.32) | 4.28 (1.26–14.59) | 0.020 | 4.04 (0.38–49.84) | 0.25 |
| Median maximum temperature (°C), (IQR) | 38.4 (37.3–39.1) | 38.7 (38.4–39.3) | 1.92 (0.78–4.69) | 0.15 | 2.28 (0.65–7.97) | 0.20 |
| Median maximum clinical score (IQR) | 4 (2–6) | 6 (4–11) | 1.19 (0.98–1.45) | 0.085 | 1.09 (0.87–1.37) | 0.45 |
| Median maximum C-reactive protein × ULN (to EOS), (IQR) | 5.4 (2.6–9.2) | 12.0 (7.2–14.2) | 1.43 (1.10–1.86) | 0.008 | 1.45 (1.05–2.01) | 0.025 |
| Median lactate dehydrogenase × ULN (to EOS), (IQR) | 0.96 (0.86–1.08) | 1.25 (1.05–1.36) | 1.56 (1.08–2.24) | 0.017 | 1.43 (0.94–2.16) | 0.093 |
ALT = alanine transaminase; EOS = end of study; IQR = interquartile range; OR = odds ratio; ULN = upper limit of normal. Odds ratio refer to a 1-unit change in the measure of the explanatory parameter (e.g., 1°C for maximum temperature). Statistically significant P-values < 0.05 are highlighted in bold.