Table 3.
Diagnostic performance of PfHRP2 and PfLDH RDTs using microscopy and qPCR as gold standard
| Microscopy as gold standard | qPCR as gold standard | |||
|---|---|---|---|---|
| Performance RDT | PfHRP2 RDT | PfLDH RDT | PfHRP2 RDT | PfLDH RDT |
| Sensitivity (95% CI) | 96 (91, 99) | 89 (81, 93) | 77 (70, 83) | 70 (62, 77) |
| Specificity (95% CI) | 93 (90, 96) | 99 (97, 100) | 93 (89, 95) | 98 (96, 99) |
| Positive predictive value (95% CI) | 84 (76, 89) | 97 (91, 99) | 85 (77, 89) | 97 (91, 99) |
| Negative predictive value (95% CI) | 99 (96, 100) | 96 (93, 98) | 89 (85, 92) | 66 (60, 70) |
| Kappa (95% CI) | 0.86 (0.80, 91) | 0.90 (0.85, 0.95) | 0.71 (0.64, 0.79) | 0.74 (0.67, 0.81) |
PfHRP2 = Plasmodium falciparum histidine-rich protein 2; PfLDH = Plasmodium falciparum lactate dehydrogenase; qPCR = quantitative PCR; RDT = rapid diagnostic test.