Figure 6. TAK-580 induces synergistic cytotoxicity with other novel agents in MM cells.

KMS-11 cells were cultured with TAK-580 (20 μM), POM (40 μM), or TAK-580 plus POM for 72 h; TAK-580 (20 μM), CFZ (1 nM), or TAK-580 plus CFZ for 24 h; TAK-580 (20 μM), IXA (30 nM), or TAK-580 plus IXA for 48 h. Apoptotic cells were analyzed with flow cytometry using annexin V/PI staining. Apoptosis was assessed as the percentage of annexin V-positive cells.