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inhibition of the PI3K/AKT pathway reverses the effects of NOB. (A) Cr levels in serum (µmol/l). (B) BUN levels in serum (mmol/l). (C) Tubular injury scores. (D) GRP78 mRNA levels. (E) CHOP mRNA levels. (F) Capase-12 mRNA levels. (G) H&E staining of renal tissues. Magnification, ×200. Scale bar, 20 µm. n=3. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. NOB, nobiletin; Cr, creatinine; I/R, ischemia/reperfusion; BUN, blood urea nitrogen; CHOP, C/EBP homologous protein.
