Figure 1.

ATG alleviates BLM-induced dermal fibrosis in a murine HS model. (A) Schematic diagram of the experiment. (B) Representative images of H&E staining of skin tissues. (C) Dermal thickness was calculated by measuring the distance from the epidermis-dermis junction to the dermis-subcutaneous tissue junction of H&E stained sections. (D) Collagen content in the skin was detected using the Sircol collagen assay kit. (E) Extracellular matrix-related gene expression levels were measured via reverse transcription-quantitative PCR. **P<0.01. ATG, arctigenin; BLM, bleomycin; HS, hypertrophic scar; H&E, Hematoxylin and eosin; Col1a1, collagen type I α1 chain; Col1a2, collagen type I α2 chain; CTGF, connective tissue growth factor; PAI-1, plasminogen activator inhibitor-1; Con, Control.