Figure 1.

Illustration of the critical time points applied in the definition of medication discontinuation event within 5 years of treatment. $T_0$ refers to the first hormonal medication entry date, and $T_{max}$ is the maximum medication entry date. $T_{max+0.5}$ re represents the 6 months after the $T_{max}$and $T_5$ is the end of the 5-year treatment protocol. A discontinuation event is experienced at $T_{max+0.5}$ when $T_{max+0.5}<T_5$ and $T_{max+0.5}$ is smaller than the end of data collection window.