Table 1.
Topics that are positively associated with a medication discontinuation event (statistically significant at the 0.05 level)
| Topic | Word samples | HR | 95% CI | p |
|---|---|---|---|---|
| 122 | xray, marrow, ekg, echo, abd, density, mets, emg, tail, echocardiogram, scann, spur, egd, endoscopy, scan, exray, scans, ultra | 1.216 | (1.013, 1.460) | 0.036 |
| 109 | came, arrived, got, went, ran, returned, moved, found, called | 1.214 | (1.065, 1.384) | 0.004 |
| 13 | diarrhea, headache, chills, vomiting, spotting, coughing, nausea, headaches, bleeding, appetite, spells, eating, cough, migraines, breath, bleed, periods, energy, shortness, urinate | 1.214 | (1.057, 1.394) | 0.006 |
| 0 | triglycerides, hdl, hemoglobin, creatinine, ferritin, glucose, bun, ldl, t3, crp, ast, protein, t4, platelet, fsh, phosphatase, wbc, serum, enzymes, sodium | 1.194 | (1.046, 1.363) | 0.008 |
| 56 | myhealthatvanderbilt, myhealth, line, online, computer, internet, sheet, summary, site, listed, list | 1.171 | (1.044, 1.313) | 0.007 |
| 44 | reconstruction, lumpectomy, mastectomy, diep, flap, bilateral, hysterectomy, surgery, procedure, ovaries, port, replacement, surgeon, uterus, iud, plastic | 1.17 | (1.012, 1.353) | 0.034 |
| 53 | irritability, irritable, worsening, sadness, intestinal, mood, swings, frequent, significantly, attacks, cognitive, functioning, appearance, swallowing, panic, vision, osteoarthritis, peripheral, inflammation, balance | 1.164 | (1.024, 1.322) | 0.02 |
| 189 | eliminate, prevent, improve, affect, reduce, minimize, impact, resolve | 1.159 | (1.045, 1.285) | 0.005 |
| 79 | negative, positive, expected, normal, tested, result, compared, spread, lead | 1.13 | (1.008, 1.267) | 0.036 |
| 192 | suppression, blocking, hormonal, induced, bkm120, osteoporosis, estrogen, nutrition, diabetes, non, hormone, holistic, bc, specifically | 1.129 | (1.003, 1.272) | 0.044 |
Note: The topics are sorted according to HR. A larger HR suggests a greater risk of medication discontinuation. For each topic in the table, we rank the words based on their average similarity with other words in the same topic. If the size of the topic is greater than 20, we display the top 20 words; otherwise, we show all of the words in the topic.