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. 2018 Oct 30;25(11):1444–1451. doi: 10.1093/jamia/ocy118

Table 2.

Topics that are negatively associated with a medication discontinuation event (statistically significant at the 0.05 level)

Topic Word samples HR 95% CI p
105 thx, thankyou, ty, thks, wishes, regards, promptly, thank, thanks, ed 0.872 (0.763, 0.997) 0.044
102 ovarian, oid, dcis, ductal, uterine, invasive, colon, stage, diagnosis, policy 0.868 (0.756, 0.996) 0.043
24 wondered, wondering, wandering, wonder, correctly, wrong 0.861 (0.757, 0.979) 0.023
157 informed, advised, notified, assured, offered, told, treated, given, diagnosed, treating 0.849 (0.741, 0.973) 0.018
106 prefer, like, mind 0.846 (0.733, 0.977) 0.023
127 happens, happening, exactly, means 0.844 (0.731, 0.975) 0.021
42 cardiologist, urologist, dermatologist, neurologist, gyn, gynecologist, psychiatrist, doc, oncologist, physician, rheumatologist, doctor, specialist, pcp, gp, friend, ob, onc, obgyn, woman 0.838 (0.729, 0.964) 0.013
187 decided, plan 0.833 (0.717, 0.968) 0.017
25 upper, pelvis, fracture, abdomen, thoracic, neck, fractured, lumbar, pelvic, wall, spine, injury, inner, rt, cervical, nerve, stimulator, injured, lower, brace 0.831 (0.705, 0.980) 0.028
85 variety, indicative, bouts, lack, importance, lots, tons, ahold, alot, signs, proof, none, course, lieu, episodes, instances, events, expense, plenty, rid 0.829 (0.715, 0.962) 0.013
2 start, begin, stop, discontinue, resume, finish, continue, restart, skip, wait 0.822 (0.704, 0.959) 0.013
38 prednisone, exemestane, wellbutrin, cymbalta, metformin, gabapentin, celexa, paxil, prozac, zoloft, levaquin, lexapro, zetia, warfarin, lyrica, methotrexate, arimidex, aromasin, effexor, lovenox 0.807 (0.682, 0.955) 0.013
136 knowledge, expertise, guidance, efforts, counsel, input, responses, feedback, kindness, recommendations, compassion, attentiveness, consideration, judgment, patience, advice, support, assistance, encouragement, suggestion 0.766 (0.645, 0.909) 0.002

Note: The topics are sorted according to their HR. A smaller HR suggests a lower risk of medication discontinuation.