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. Author manuscript; available in PMC: 2020 Nov 6.
Published in final edited form as: Eur J Neurol. 2017 Sep 28;25(1):41–58. doi: 10.1111/ene.13412

Table 3.

Neuroimaging

Characteristic MRI findings
MSA ‘Hot-cross bun’ sign (pontine T2 hyperintensity)
Putaminal rim sign (T2 hyperintense rim of dorsolateral putaminal border)
Atrophy of pons, cerebellum, middle cerebellar peduncle
PSP ‘Hummingbird sign’ (more severe midbrain than pontine atrophy)
‘Morning glory sign’ (atrophy of midbrain tegmentum)
Atrophy of midbrain, tegmentum, superior cerebellar peduncles
CBS Asymmetric atrophy in parietal and (pre)frontal cortices
bvFTD Frontal and anterior temporal atrophy (more pronounced in non-dominant hemisphere)
svPPA Anterior temporal atrophy (dominant hemisphere)
navPPA Atrophy of the inferior frontal cortex (dominant hemisphere)
lvPPA Posterior temporal and parietal atrophy (dominant hemisphere)