Figure 10.

Effects of CRT on SirT1 expression in ATO-induced cardiotoxicity in rats. (A) Protein expression of SirT1 was measured using western blotting. (B) Relative intensities of SirT1 were analyzed after normalizing to β-actin. The myocardial tissues were obtained from the Con, ATO, CRT-L and CRT-H groups. Data are presented as the mean ± SEM for each group, n=10. **P<0.01 vs. Con group; ^##P<0.01 vs. ATO group. CRT, crocetin; Con, control; ATO, arsenic trioxide; CRT-L, ATO + low concentration of CRT treatment group; CRT-H, ATO + high concentration of CRT treatment group; SirT1, silent information regulator of transcription 1.