Table 2. Summary of differentially expressed immune response genes associated with programmed cell death pathways within MCMV-infected eyes of groups of healthy mice, MAIDS-4 mice, and MAIDS-10 mice.
| Fold Change of MCMV-infected Eyes of Healthy Mice | |||||||
| Cell Death Pathway | Genes | Day 3 | Day 6 | Day 10 | |||
| Δ | p value | Δ | p value | Δ | p value | ||
| Autophagy | Atg12 | 1.07 | 0.3855 | 1.24 | 0.0792 | 1.14 | 0.1344 |
| Autophagy | Atg5 | -1.05 | 0.0155 | -1.13 | 0.0269 | -1.02 | 0.0047 |
| Autophagy | Becn1 | 0.05 | 0.5346 | -0.05 | 0.5090 | 1.07 | 0.3855 |
| Necroptosis | Mlkl | -3.53 | 0.1688 | -1.59 | 0.0012 | -4.34 | 0.0500 |
| Necroptosis | Ripk1 | -1.46 | 0.0491 | -1.31 | 0.0248 | -1.63 | 0.0048 |
| Necroptosis | Ripk3 | -2.34 | 0.0983 | -2.01 | 0.0632 | -2.87 | 0.0016 |
| Parthanatos | Parg | 1.07 | 0.1772 | 1.24 | 0.2209 | 0.02 | 0.5158 |
| Parthanatos | Parp1 | 0.07 | 0.5445 | 1.33 | 0.0385 | 1.11 | 0.1695 |
| Inflammasome/Pyroptosis | Aim2 | -2.27 | 0.0457 | -1.45 | 0.0013 | -2.07 | 0.0073 |
| Inflammasome/Pyroptosis | Casp11 | -6.83 | 0.2365 | -2.86 | 0.0683 | -7.90 | 0.1394 |
| Inflammasome/Pyroptosis | Gsdmd | -2.64 | 0.0437 | -1.95 | 0.0636 | -2.91 | 0.0033 |
| Inflammasome/Pyroptosis | Nlrc4 | -3.78 | 0.1043 | -1.81 | 0.1011 | -4.14 | 0.0538 |
| Inflammasome/Pyroptosis | Nlrp1b | -0.01 | 0.5154 | -0.07 | 0.5284 | -1.24 | 0.0510 |
| Inflammasome/Pyroptosis | Nlrp3 | -2.42 | 0.0483 | -0.01 | 0.5328 | -2.25 | 0.0837 |
| Fold Change of MCMV-infected Eyes of MAIDS-4 Mice | |||||||
| Cell Death Pathway | Genes | Day 3 | Day 6 | Day 10 | |||
| Δ | p value | Δ | p value | Δ | p value | ||
| Autophagy | Atg12 | 0.05 | 0.5378 | -1.13 | 0.0314 | -0.44 | 0.5109 |
| Autophagy | Atg5 | 1.52 | 0.2518 | 1.19 | 0.0172 | 0.10 | 0.6342 |
| Autophagy | Becn1 | 1.25 | 0.3402 | 1.19 | 0.0855 | 0.05 | 0.5810 |
| Necroptosis | Mlkl | 4.73 | 0.1322 | 6.69 | 0.0625 | 6.01 | 0.2067 |
| Necroptosis | Ripk1 | 1.98 | 0.1282 | 2.25 | 0.1306 | 2.34 | 0.0547 |
| Necroptosis | Ripk3 | 3.18 | 0.2738 | 4.49 | 0.2026 | 5.29 | 0.0467 |
| Parthanatos | Parg | -0.03 | 0.5322 | -0.13 | 0.5056 | -1.28 | 0.0612 |
| Parthanatos | Parp1 | 1.06 | 0.5000 | 1.21 | 0.1669 | -1.49 | 0.1188 |
| Inflammasome/Pyroptosis | Aim2 | 2.56 | 0.0470 | 2.72 | 0.1099 | 3.03 | 0.0995 |
| Inflammasome/Pyroptosis | Casp11 | 8.74 | 0.1416 | 11.25 | 0.0666 | 8.81 | 0.0533 |
| Inflammasome/Pyroptosis | Gsdmd | 3.59 | 0.0783 | 5.05 | 0.1068 | 3.59 | 0.1095 |
| Inflammasome/Pyroptosis | Nlrc4 | 7.67 | 0.1999 | 7.40 | 0.0953 | 4.61 | 0.0291 |
| Inflammasome/Pyroptosis | Nlrp1b | 1.58 | 0.2863 | 1.74 | 0.1732 | 4.54 | 0.2836 |
| Inflammasome/Pyroptosis | Nlrp3 | 4.23 | 0.1047 | 3.41 | 0.0672 | 3.64 | 0.1983 |
| Fold Change of MCMV-infected Eyes of MAIDS-10 Mice | |||||||
| Cell Death Pathway | Genes | Day 3 | Day 6 | Day 10 | |||
| Δ | p value | Δ | p value | Δ | p value | ||
| Autophagy | Atg12 | -0.07 | 0.5202 | 1.19 | 0.3286 | 1.08 | 0.0424 |
| Autophagy | Atg5 | 1.32 | 0.0101 | 1.36 | 0.1665 | 1.69 | 0.0092 |
| Autophagy | Becn1 | 1.41 | 0.0465 | 1.28 | 0.2578 | 1.59 | 0.1850 |
| Necroptosis | Mlkl | 5.75 | 0.1482 | 4.16 | 0.1853 | 3.43 | 0.1166 |
| Necroptosis | Ripk1 | 2.20 | 0.0978 | 1.96 | 0.0565 | 2.17 | 0.0272 |
| Necroptosis | Ripk3 | 3.80 | 0.0057 | 3.93 | 0.0228 | 4.14 | 0.0091 |
| Parthanatos | Parg | -1.14 | 0.0119 | 1.21 | 0.2048 | -1.26 | 0.0085 |
| Parthanatos | Parp1 | -0.13 | 0.5111 | 1.19 | 0.1190 | -1.63 | 0.0736 |
| Inflammasome/Pyroptosis | Aim2 | 2.08 | 0.1594 | 2.44 | 0.0244 | 2.04 | 0.1032 |
| Inflammasome/Pyroptosis | Casp11 | 12.65 | 0.0358 | 5.07 | 0.1811 | 5.83 | 0.0631 |
| Inflammasome/Pyroptosis | Gsdmd | 4.41 | 0.0707 | 2.68 | 0.1036 | 3.63 | 0.0073 |
| Inflammasome/Pyroptosis | Nlrc4 | 7.20 | 0.2324 | 6.05 | 0.3290 | 4.23 | 0.0659 |
| Inflammasome/Pyroptosis | Nlrp1b | -0.10 | 0.5529 | 1.80 | 0.3369 | 1.12 | 0.3362 |
| Inflammasome/Pyroptosis | Nlrp3 | 3.08 | 0.0882 | 3.36 | 0.1534 | 1.40 | 0.2788 |