Table 1:
Relevant mouse models.
Model | Primary organ site | Lineage label | Definition of EMT | Reference |
---|---|---|---|---|
MMTV-PyMT MMTV-Cre |
Breast |
RosaLSL-YFP Ecad-mCFP |
YFP+/mCFPlow EMT cells | [17] |
MMTV-PyMT | Breast |
Fsp-Cre RosaloxP-RFP-STOP-loxP-GFP |
RFP−/GFP+ EMT cells after Fsp-cre mediated recombination | [18] |
MMTV-Her2/c-neu/Erbb2 | Breast | Snail-YFP | YFP+ EMT cells after induction of Snail during EMT | [21] |
“KPCY” KrasLSL-G12D p53LSL-R172H or loxP Pdx1-Cre |
Pancreas | RosaLSL-YFP | YFP+/ECAD− EMT cells | [22] |
Pb-Cre PtenloxP/loxP KrasLSL-G12D |
Prostate | Vimentin-GFP | GFP+/EpCAM− EMT cells after induction of Vimentin during EMT | [24] |
AT3 tumor cell injection | Prostate | CMV-loxP-DsRed-Stop-loxP-eGFP | RFP+ cells that have undergone EMT and GFP+ cells that remain epithelial | [71] |