Table 1.
Override rates for high-priority DDI alerts
| Specific DDI | Total alerts (excluding filtered alerts) | Overridden alerts |
|---|---|---|
| Ondansetron–QT-prolonging agents | 10 251 | 9897 (96.5) |
| Simvastatin (>20 mg)–amlodipine | 1962 | 1886 (96.1) |
| Other QT-prolonging agents (includes 1 level 1 DDI with 21 overrides)a | 1519 | 1450 (95.5) |
| Warfarin–sulfonamides | 757 | 706 (93.3) |
| Amiodarone–QT-prolonging agents | 713 | 689 (95.1) |
| Amiodarone; dronedarone–digitalis glycosides | 465 | 442 (95.1) |
| Tizanidine–ciprofloxacina | 116 | 100 (86.2) |
| Lithium–thiazide diuretics | 42 | 36 (85.7) |
| Valproic acid–carbapenem antibiotics | 42 | 40 (95.2) |
| Abatacept–TNF-blocking agentsa | 28 | 24 (85.7) |
| Dofetilide–thiazide diureticsa | 23 | 20 (87.0) |
| Ramelteon–fluvoxaminea | 14 | 13 (92.9) |
| Atazanavir; nelfinavir–proton pump inhibitorsa | 11 | 10 (90.0) |
| Efalizumab/natalizumab–immunosuppressants/immunomodulatorsa | 6 | 5 (83.3) |
| Filtered alertsb | ||
| 5HT-1D agonists (triptans)–SSRIs; SNRIs | 40 | 0 (0) |
| Amiodarone–warfarin | 11 | 0 (0) |
| Warfarin–metronidazole; tinidazole | 11 | 0 (0) |
| Total | 16 011 | 15 318 (95.7) |
5HT-1D: 5-hydroxytryptamine (serotonin) receptor 1D; DDI: drug–drug interaction; SNRI: selective norepinephrine reuptake inhibitor; SSRI: selective serotonin reuptake inhibitor; TNF: tumor necrosis factor.
a
Highest-severity alert.
b
Overridden alerts not included for filtered alerts (includes cancelled order).