Fig. 8.

(A) Radar plot of four prototype compounds N3, 13b, Disulfiram, Carmofur after calculating ADME data (http://www.swissadme.ch/) suggesting the drug-likeness. Pink area represents the optimal range of each property. LIPO = Lipophilicity, SIZE = Molecular weight, POLAR = Polarity, INSOLU = Solubility, INSATU = Saturation, FLEX = Flexibility; (B) Correlation of SARS-CoV-2 Mpro inhibitory activity with eleven molecular descriptors (N = 25); (C) The correlation matrix of the physic-chemical and structural properties along with SARS-CoV-2 Mpro pIC₅₀ (N = 25) at significant p-statics; (D) The correlation matrix of the ADME properties along with SARS-CoV-2 Mpro pIC₅₀ (N = 25) at significant p-statics.