Table 1.

List of amino acid residues play important role in SARS-CoV-2 Mpro.

Role in SARS-CoV-2 Mpro	Residue
Catalytic dyad	H41, C145
Substrate binding	H41, M49, G143, S144, H163, H164, M165, E166, L167, D187, R188, Q189, T190, A191, Q192
Dimerization	R4, S10, G11, E14, N28, S139, F140, S147, E290, R298