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. 2020 Nov 6;29:115860. doi: 10.1016/j.bmc.2020.115860

Table 2.

List of amino acid residues play key role in SARS-CoV-2 PLpro.

Role in SARS-CoV-2 PLpro Residue
Catalytic triad C111, H272, D286
Substrate binding Y268, M208, P247, P248, T301, P248, Y264, N267, Q269, L162, C270, G271 and Y273