Table 3.
Reported SARS-CoV-2 Mpro inhibitors and biological properties.
| Entry | Name | SARS-CoV-2 Mpro IC50 (µM) | pIC50 |
|---|---|---|---|
| 1 | N3 | – | – |
| 2 | Ebselen | 0.67 | 6.174 |
| 3 | Disulfiram | 9.35 | 5.029 |
| 4 | Tideglusib | 1.55 | 5.810 |
| 5 | Carmofur | 1.82 | 5.740 |
| 6 | Shikonin | 15.75 | 4.803 |
| 7 | PX-12 | 21.39 | 4.670 |
| 8 | Cinanserin | 124.93 | 3.903 |
| 9 | 11a | 0.053 | 7.276 |
| 10 | 11b | 0.04 | 7.398 |
| 11 | 11r | 0.18 | 6.745 |
| 12 | 13a | 2.39 | 5.622 |
| 13 | 13b | 0.67 | 6.174 |
| 14 | 14b | – | – |
| 15 | Simeprevir | 13.74 | 4.862 |
| 16 | Boceprevir | 4.13 | 5.384 |
| 17 | Narlaprevir | 5.73 | 5.242 |
| 18 | MG-132 | 3.9 | 5.409 |
| 19 | Calpeptin | 10.69 | 4.971 |
| 20 | Calpain inhibitor III | >20 | – |
| 21 | Calpain inhibitor VI | >20 | – |
| 22 | Calpain inhibitor I (ALLN) | 8.6 | 5.066 |
| 23 | MG-115 | 3.14 | 5.503 |
| 24 | Calpain inhibitor II (ALLM) | 0.97 | 6.013 |
| 25 | Calpain inhibitor XII | 0.45 | 6.347 |
| 26 | PSI | 10.38 | 4.984 |
| 27 | GC-376 | 0.03 | 7.523 |
| 28 | Rupintrivir | >20 | – |
| 29 | Camostat | >20 | – |
| 30 | Lopinavir | >20 | – |
| 31 | Ritonavir | >20 | – |
| 32 | Baicalin | 6.41 | 5.193 |
| 33 | Baicalein | 0.94 | 6.027 |