Table 2.
Meta-analysis of the association between 18 polymorphisms of 7 genes and pediatric asthma risk.
| Test of association | Test of heterogeneity | Begg test | ||||||||
| Gene | Polymorphism | Comparison | N | OR (95% CI) | P | Model | Ph | I2/% | z | P |
| IL-13 | +2044G/A | GA+AA vs GG | 6 | 1.73 (1.16–2.56) | .01 | R | 0.00 | 70.8 | 1.32 | .26 |
| AA vs GG+GA | 1.04 (0.84–1.20) | .72 | F | 0.14 | 39.9 | 1.13 | .26 | |||
| A vs G | 1.42 (1.05–1.91) | .02 | R | 0.00 | 77.5 | 2.63 | .01 | |||
| AA vs GG | 1.66 (0.98–2.82) | .06 | R | 0.03 | 58.4 | 1.13 | .26 | |||
| AG vs GG | 1.70 (1.18–2.45) | .01 | R | 0.02 | 62.6 | 1.13 | .26 | |||
| −1112C/T | CT+TT vs CC | 6 | 1.31 (0.72–1.78) | .59 | R | 0.00 | 90.0 | 0.60 | .55 | |
| TT vs CC+CT | 1.05 (0.59–1.87) | .87 | R | 0.00 | 79.7 | 0.90 | .37 | |||
| T vs C | 1.06 (0.73–1.54) | .75 | R | 0.00 | 91.1 | 0.30 | .76 | |||
| TT vs CC | 1.72 (0.76–3.90) | .20 | R | 0.00 | 83.6 | 1.20 | .23 | |||
| CT vs CC | 1.14 (0.73–1.78) | .56 | R | 0.00 | 88.4 | 0.00 | 1.00 | |||
| +1923C/T | CT+TT vs CC | 4 | 1.09 (0.54–2.21) | .82 | R | 0.00 | 85.9 | −0.34 | 1.00 | |
| TT vs CC+CT | 1.06 (0.43–2.60) | .91 | R | 0.00 | 76.4 | −0.34 | 1.00 | |||
| T vs C | 1.08 (0.64–1.82) | .78 | R | 0.00 | 86.9 | −0.34 | 1.00 | |||
| TT vs CC | 1.07 (0.37–3.06) | .91 | R | 0.00 | 80.4 | −0.34 | 1.00 | |||
| CT vs CC | 1.09 (0.55–2.14) | .80 | R | 0.00 | 83.1 | −0.34 | 1.00 | |||
| IL-4 | −590C/T | CT+TT vs CC | 14 | 1.37 (1.04–1.82) | .03 | R | 0.02 | 51.6 | 0.33 | .74 |
| TT vs CC+CT | 1.23 (1.02–1.49) | .03 | R | 0.01 | 52.3 | 1.31 | .19 | |||
| T vs C | 1.24 (1.04–1.48) | .02 | R | 0.00 | 70.0 | 0.55 | .58 | |||
| TT vs CC | 1.49 (1.05–2.12) | .03 | R | 0.12 | 50.6 | 0.11 | .91 | |||
| CT vs CC | 1.26 (1.04–1.52) | .02 | F | 0.09 | 35.5 | 0.55 | .58 | |||
| ADRB2 | −46 G /A | GA+GG vs AA | 12 | 1.22 (0.88–1.70) | .24 | R | 0.00 | 79.1 | 1.30 | .19 |
| GG vs GA+AA | 0.97 (0.69–1.35) | .84 | R | 0.00 | 75.7 | 0.07 | .95 | |||
| G vs A | 1.10 (0.86–1.40) | .46 | R | 0.00 | 84.3 | 1.17 | .24 | |||
| GG vs AA | 1.09 (0.71–1.67) | .69 | R | 0.00 | 78.4 | 0.62 | .54 | |||
| GA vs AA | 1.26 (0.93–1.73) | .14 | R | 0.00 | 72.6 | 2.54 | .01 | |||
| −79G/C | GC+GG vs CC | 7 | 1.12 (0.84–1.50) | .44 | R | 0.05 | 51.9 | 1.20 | .23 | |
| GG vs GC+CC | 1.04 (0.68–1.60) | .85 | F | 0.77 | 0.00 | 0.60 | .55 | |||
| G vs C | 1.08 (0.86–1.36) | .52 | R | 0.06 | 50.3 | 0.90 | .37 | |||
| GG vs CC | 1.12 (0.72–1.72) | .62 | F | 0.63 | 0.00 | 1.50 | .13 | |||
| GC vs CC | 1.10 (0.90–1.35) | .35 | F | 0.09 | 45.8 | 0.60 | .55 | |||
| ADAM33 | F+1 | CT+TT vs CC | 1.24 (1.04–1.48) | .02 | F | 0.13 | 44.3 | 0.24 | .81 | |
| TT vs TC+CC | 1.67 (0.94–2.97) | .08 | R | 0.00 | 79.0 | 0.24 | .81 | |||
| T vs C | 1.33 (0.99–1.79) | .06 | R | 0.00 | 80.0 | −0.24 | 1.00 | |||
| TT vs CC | 1.81 (0.95–3.44) | .07 | R | 0.00 | 79.1 | −0.24 | 1.00 | |||
| CT vs CC | 1.13 (0.93–1.36) | .21 | F | 0.93 | 0.0 | 0.73 | .46 | |||
| V4 | GC+GG vs CC | 5 | 1.02 (0.47–2.22) | .96 | R | 0.00 | 90.4 | 1.22 | .22 | |
| CC vs CG+CC | 1.15 (0.44–3.01) | .78 | R | 0.00 | 95.2 | 0.24 | .81 | |||
| G vs C | 0.99 (0.47–2.09) | .99 | R | 0.00 | 97.1 | −0.24 | 1.00 | |||
| GG vs CC | 1.22 (0.34–4.32) | .76 | R | 0.00 | 94.2 | 0.24 | .81 | |||
| GC vs CC | 1.17 (0.66–2.08) | .59 | R | 0.00 | 79.3 | 0.73 | .46 | |||
| S2 | GC+CC vs GG | 6 | 0.99 (0.28–3.43) | .00 | R | 0.00 | 92.7 | 0.38 | .71 | |
| CC vs GC+GG | 1.40 (0.54–3.60) | .49 | R | 0.00 | 95.5 | 1.50 | .13 | |||
| C vs G | 1.17 (0.57–2.42) | .67 | R | 0.00 | 95.8 | 0.00 | 1.00 | |||
| CC vs GG | 1.07 (0.23–4.93) | .93 | R | 0.00 | 94.2 | 0.00 | 1.00 | |||
| GC vs GG | 0.99 (0.36–2.69) | .98 | R | 0.00 | 87.2 | 0.75 | .45 | |||
| T2 | AG+AA vs GG | 4 | 1.87 (1.07–3.27) | .03 | R | 0.00 | 84.4 | −0.34 | 1.00 | |
| AA vs GA+GG | 3.72 (1.98–6.98) | .00 | F | 0.27 | 23.1 | 0.34 | .73 | |||
| A vs G | 1.86 (1.10–3.15) | .02 | R | 0.00 | 86.2 | −0.34 | 1.00 | |||
| AA vs GG | 4.25 (2.27–7.98) | .00 | F | 0.15 | 43.4 | 0.34 | .73 | |||
| AG vs GG | 1.71 (1.03–2.85) | .04 | R | 0.00 | 79.2 | −0.34 | 1.00 | |||
| T1 | GA+GG vs AA | 4 | 2.12 (1.29–3.47) | .00 | R | 0.01 | 75.2 | 1.02 | .31 | |
| GG vs GA+AA | 1.70 (0.65–4.45) | .28 | R | 0.00 | 87.3 | 0.34 | .73 | |||
| G vs A | 1.54 (0.90–2.65) | .12 | R | 0.00 | 90.1 | 1.70 | .90 | |||
| GG vs AA | 4.11 (2.56–5.90) | .00 | F | 0.03 | 67.2 | 1.02 | .31 | |||
| GA vs AA | 2.05 (1.37–3.08) | .00 | R | 0.06 | 60.0 | 0.34 | .73 | |||
| ST+4 | AC+CC vs AA | 3 | 1.74 (1.37–2.39) | .00 | F | 0.37 | 0.0 | 1.04 | .30 | |
| CC vs AC+AA | 1.81 (1.31–2.30) | .00 | F | 0.47 | 0.0 | 0.00 | 1.00 | |||
| C vs A | 1.57 (1.32–1.87) | .00 | F | 0.62 | 0.0 | 0.00 | 1.00 | |||
| CC vs AA | 2.19 (1.55–3.12) | .00 | F | 0.56 | 0.0 | 1.04 | .30 | |||
| AC vs AA | 1.59 (1.18–2.13) | .00 | F | 0.16 | 45.2 | 1.04 | .30 | |||
| ORMDL3 | rs7216389 | CT+TT vs CC | 2.44 (1.68–3.55) | .00 | F | 0.91 | 0.00 | 0.34 | .73 | |
| TT vs TC+CC | 1.80 (1.43–2.26) | .00 | F | 0.84 | 0.0 | −0.34 | 1.00 | |||
| T vs C | 1.89 (1.57–2.27) | .00 | F | 0.78 | 0.0 | 0.34 | .73 | |||
| TT vs CC | 2.92 (1.98–4.32) | .00 | F | 0.90 | 0.0 | 0.34 | .73 | |||
| CT vs CC | 1.76 (1.14–2.72) | .01 | F | 0.92 | 0.0 | 0.34 | .73 | |||
| VDR | ApaI | CC+CA vs AA | 7 | 1.21 (0.60–2.41) | .60 | R | 0.00 | 84.1 | 0.30 | .76 |
| CC vs AC+AA | 0.87 (0.59–1.30) | .51 | R | 0.08 | 49.3 | 0.38 | .71 | |||
| C vs A | 1.11 (0.67–1.84) | .68 | R | 0.00 | 83.6 | 0.00 | 1.00 | |||
| CC vs AA | 0.93 (0.40–2.14) | .86 | R | 0.01 | 66.1 | 0.38 | .71 | |||
| CA vs A | 1.31 (0.65–2.61) | .45 | R | 0.00 | 81.5 | 0.00 | 1.00 | |||
| FokI | CC+CT vs TT | 7 | 0.74 (0.57–0.96) | .02 | F | 0.14 | 37.5 | 0.30 | .76 | |
| CC vs TC+TT | 0.76 (0.42–1.38) | .37 | R | 0.04 | 57.6 | 0.00 | 1.00 | |||
| C vs T | 0.79 (0.59–1.07) | .13 | R | 0.02 | 61.6 | 0.30 | .76 | |||
| CC vs TT | 0.64 (0.30–1.40) | .27 | R | 0.01 | 66.1 | 0.00 | 1.00 | |||
| CT vs TT | 0.79 (0.60–1.04) | .09 | F | 0.46 | 0.0 | 0.00 | 1.00 | |||
| BsmI | GG+GA vs AA | 6 | 1.40 (0.59–3.36) | .45 | F | 0.00 | 74.4 | 0.38 | .71 | |
| GG vs GA+AA | 0.82 (0.56–1.21) | .31 | F | 0.82 | 0.0 | 0.00 | 1.00 | |||
| G vs A | 1.20 (0.59–2.47) | .61 | R | 0.00 | 78.0 | 0.75 | .45 | |||
| GG vs AA | 0.56 (0.32–0.97) | .39 | F | 0.22 | 33.5 | 0.00 | 1.00 | |||
| GA vs AA | 1.52 (0.61–3.77) | .37 | R | 0.00 | 74.4 | 0.38 | .71 | |||
| TaqI | TT+CT vs CC | 5 | 0.86 (0.55–1.35) | .51 | R | 0.07 | 53.6 | 0.24 | .81 | |
| TT vs CC+CT | 0.45 (0.29–0.71) | .00 | F | 0.19 | 37.2 | 0.34 | .73 | |||
| T vs C | 0.78 (0.64–0.96) | .02 | F | 0.24 | 26.7 | 0.24 | .81 | |||
| TT vs CC | 0.52 (0.32–0.85) | .01 | F | 0.36 | 7.2 | 0.34 | .73 | |||
| CT vs CC | 0.96 (0.55–1.66) | .87 | R | 0.02 | 64.3 | 0.24 | .81 | |||
| CTLA-4 | +49 A/G | AG+AA vs GG | 3 | 1.20 (0.50–2.89) | .68 | R | 0.03 | 71.1 | 0.00 | 1.00 |
| AA vs AG+GG | 1.51 (0.40–5.70) | .54 | R | 0.02 | 73.8 | 0.00 | 1.00 | |||
| A vs G | 1.22 (0.52–2.88) | .64 | R | 0.00 | 84.3 | 0.00 | 1.00 | |||
| AA vs GG | 1.48 (0.30–7.40) | .63 | R | 0.01 | 78.8 | 0.00 | 1.00 | |||
| AG vs GG | 1.28 (0.84–1.95) | .24 | F | 0.20 | 37.2 | 1.04 | .30 | |||