Table 2.
Currently Available FDA-approved Soft-tissue Fillers
| Trade Name | Material | HA Concentration (mg/mL) | Manufacturer | Approval Year | Duration (mo) | G* (Pa) | n* (Viscosity) | Cohesivity (DW, mg) | Approved Indication |
|---|---|---|---|---|---|---|---|---|---|
| Restylane Lyft* | HA ± Lidocaine | 20 | Galderma Laboratories | 2003, 2011, 2018 | 6–9 | 549 | 127,090 | 14 | Moderate to severe facial wrinkles Cheek augmentation and midface contour deficiencies Lip augmentation Dorsal hand volume deficit |
| Restylane Refyne and Defyne | Sodium Hyalauronate | 20 | Galderma Laboratories | 2016 | 6–9 | 48, 260 | NA | 28 22 | Facial wrinkles and folds |
| Restylane Silk | HA ± Lidocaine | 20 | Galderma Laboratories | 2014 | 6–9 | 353 | 107 | 18 | Lip augmentation Perioral rhytids |
| Restylane-L | HA + Lidocaine | 20 | Galderma Laboratories | 2012 | 6–9 | NA | 131,310 | NA | Facial wrinkles and folds Lip augmentation |
| Restylane | HA | 20 | Galderma Laboratories | 2011 | 6–9 | 553 | 119,180 | 15 | Lip augmentation |
| Sculptra Aesthetic | PLLA | NA | Galderma Laboratories | 2009 2004 | 12–24 | NA | NA | NA | Nasolabial contour deficiencies Facial wrinkles Lipoatrophy in HIV patients |
| Revanesse Versa | HA ± Lidocaine | 22–28 | Prollenium Medical Technologies Inc. | 2018 | 6–12 | NA | NA | NA | Facial wrinkles and folds |
| Juvederm Ultra XC | HA ± Lidocaine | 24 | Allergan | 2010 | 12 | 78 | 27,034 | 29 | Facial wrinkles and folds Lip augmentation |
| Juvederm Vollure XC | HA + Lidocaine | 17.5 | Allergan | 2017 | 12–18 | 275 | NA | 16 | Facial wrinkles and folds |
| Juvederm Volbella XC | HA + Lidocaine | 15 | Allergan | 2016 | 12 | 161 | NA | 15 | Lip augmentation Perioral rhytids |
| Juvederm Voluma XC | HA | 20 | Allergan | 2013 | 12–24 | 308 | 310,000 | 18 | Cheek augmentation and midface contour deficiencies |
| RHA 2 | HA ± Lidocaine | 23 | Clarion Medical Technologies | 2017 | 6–9 | 148, 186, 298 | NA | 26 | Facial wrinkles and folds |
| RHA 3 | |||||||||
| RHA 4 | |||||||||
| Belotero Balance | HA | 22.5 | Merz Pharmaceuticals | 2011 | 45 | 9,217 | 48 | Facial wrinkles and folds | |
| Radiesse | Hydroxylapatite | NA | Merz Pharmaceuticals | 2006 | 12–15 | NA | 349,830 | NA | Facial wrinkles and folds Lipoatrophy in HIV patients. |
| Bellafill | PMMA, Collagen + Lidocaine | NA | Suneva Medical, Inc. | 2006 | 12–72 | NA | NA | NA | Perioral |