Figure 1.

B Cell Infiltration in Human Pancreatic Ductal Adenocarcinoma

In (A)–(C), human PDAC tissues were stained for CD3, CD19, and CK19 by multiplex immunohistochemistry. (A) Representative images showing four patterns of CD19⁺ B cell infiltration in PDAC. Scale bars, 100 μm. (B) Quantification of CD19 and CD3 expression in human PDAC tissues (n = 11). Statistical significance was evaluated using a Mann-Whitney test. (C) Correlation plot of number of CD3⁺ cells per mm² versus number of CD19⁺ cells per mm². Data points represent quantification of individual 5X fields captured across stained human PDAC tissues (n = 11). Spearman correlation was performed for r and p value (two-tailed). (D) Correlation plot showing gene expression of CD3E and CD19 in human pancreatic adenocarcinoma (PAAD) patient samples (n = 179) downloaded from The Cancer Genome Atlas (TCGA) dataset. Pearson correlation was performed for r and p value (two-tailed).