Figure 4.

Cytokine Release after CART Cell Infusion

(A–F) Serum cytokines, including (A) IL-10, (B) IL-12, (C) IL-6, (D) IFN-γ, (E) IP-10 (CXCL10), and (F) MIG (CXCL9) were detected in the peripheral blood at defined time points after CART cell infusion. Shown in each left panel is comparison of cytokine levels detected pre-infusion (Pre) and at day 10 post-infusion. In right panel, fold change in cytokine levels are depicted over time. Statistical significance was determined by paired t test. ∗p < 0.05.