Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A Scheme of the Proposed Mechanisms
Trastuzumab treatment increases the H3K27ac enrichment at the ZNF649-AS1 promoter region, inducing upregulation of ZNF649-AS1, which thereby increases ATG5 expression by guiding PTBP1 to activate its transcription. Then, increased ATG5 protein induced autophagy and trastuzumab resistance.
