Table 1.
Summary of the Key Findings Regarding the Important Role of the xCT Molecule in Various Aspects of Cancer
| Content | Aspect of Cancer | References | Year |
|---|---|---|---|
| Ferroptosis induced in PDAC through cysteine depletion | ferroptosis | Badgley et al.14 | 2020 |
| SLC7A11 overexpression sensitizes cancer cells to GLUT inhibition | chemosensitivity | Liu et al.38 | 2020 |
| ARID1A maintains GSH homeostasis by enhancing xCT transcription | apoptosis | Ogiwara et al.39 | 2019 |
| INFγ released from CD8+ T cells inhibits xCT and promotes ferroptosis | ferroptosis | Wang et al.11 | 2019 |
| Radiotherapy and immunotherapy promote ferroptosis via synergistic repression of xCT | ferroptosis | Lang et al.40 | 2019 |
| Systemic depletion of cyst(e)ine with cyst(e)inase suppresses tumor growth in multiple cancer | tumor growth | Cramer et al.10 | 2017 |
| CD8+ T cells abrogate chemoresistance by altering GSH/cystine metabolism | chemoresistance | Wang et al.9 | 2016 |
| By repressing SLC7A11 transcription, p53 activation reduces cystine uptake and promotes ferroptosis | ferroptosis | Jiang et al.41 | 2015 |
| Glutamine sensitivity analysis identifies xCT as a therapeutic target in triple-negative breast tumor | tumor growth | Timmerman et al.42 | 2013 |
| Stromal control of cystine metabolism promotes CLL cell survival | apoptosis | Zhang et al.7 | 2012 |
| CD44 variant regulates redox status by stabilizing xCT and promotes tumor growth | tumor growth | Ishimoto et al.6 | 2011 |