Figure 7.

The Biological Role of tsRNA in Cancer Progression and Apoptosis

(A) Destabilization of oncogenic transcripts. YBX1 binds to oncogenic transcripts and protects them from degradation. Internal tsRNAs interact with YBX1, leading to sequestration of YBX1. As a result, oncogenic transcripts are degraded. (B) Suppression of oncogenic transcripts is shown. ThrAGT-1-1-typeII-tsRNA binds to TCL1 mRNA and post-transcriptionally represses its protein product, leading to inhibition of CLL development. (C) Inhibition of apoptosis is shown. tsRNA binds to cytochrome C (Cyt C) and inhibits apoptosome formation, thus promoting cell survival.