Table 3.
Expression of adipokines in SSc-related tissues and cells.
| Adipokine | Change compared with control | Tissue/cells | References |
|---|---|---|---|
| Adiponectin | ↓ in adiponectin levels in dcSSc | Skin tissue | (28) |
| ↓ in the expression of adiponectin in SSc and IPF | Lung tissue | (51) | |
| ↓ in the expression of adiponectin in SSc | Gastric tissue | (51) | |
| increased amounts of CD4+ T helper cells in adiponectin-positive tissue | Gastric tissue | (51) | |
| Apelin | ↓ in the expression of apelin | SSc dermal fibroblasts | (40) |
| Chemerin | ↑ in the expression in small blood vessels of SSc | ||
| ↓ in the expression in dermal fibroblasts surrounded with thickened collagen bundles | SSc lesional skin | (35) | |
| Leptin | ↑ in the secretion by ECs from IPAH patients | ECs | (52) |
| Lipocalin-2 | ↑ in the expression in dermal fibroblasts and ECs | SSc lesional skin | (39) |
| Resistin | ↑ in the expression of visfatin within lymphocyte infiltrates | Lung tissue | (51) |
| Visfatin | ↑ in the expression of visfatin within lymphocyte infiltrates | Lung tissue | (51) |
dcSSC: diffuse cutaneous systemic sclerosis; SSC: systemic sclerosis; IPF: idiopathic pulmonary fibrosis; EC: endothelial cells; IPAH: idiopathic pulmonary arterial hypertension.