Table 1.

Main pathways associated with differentiation between NB, WS, and WB breasts and their most important metabolites.¹

Pathways	Important metabolites (red in the map)	Raw P	-Log(p)	FDR	Impact
WS vs. WB
Cysteine and methionine metabolism	Pyruvate	0.04057	3.204	0.314	0.120
Glutathione metabolism	Glutamate	0.06117	2.794	0.314	0.406
Taurine and hypotaurine metabolism	Taurine	0.05476	2.904	0.316	0.500
Glycine, serine and threonine metabolism	Choline and pyruvate	0.07524	2.587	0.314	0.580
Glutamine and glutamate metabolism	Glutamate	0.10587	2.245	0.314	1
Phenylalanine, tyrosine and tryptophan biosynthesis	Tyrosine	0.12283	2.096	0.314	1
NB vs. WS
Taurine and hypotaurine metabolism	Taurine	0.00250	5.990	0.050	0.500
Nicotinate and nicotinamide metabolism	NAD+	0.00579	5.151	0.050	0.372
Aminoacyl-tRNA biosynthesis	Arginine, serine and threonine	0.00462	5.376	0.050	0.187
Arginine and proline metabolism	Arginine and glutamate	0.00482	5.334	0.050	0.269
Glycine, serine and threonine metabolism	Threonine	0.05154	2.965	0.129	0.586
β-Alanine metabolism	Aspartate and β-Alanine	0.02813	3.570	0.116	0.521
Glutamine and glutamate metabolism	Glutamate	0.04457	3.110	0.129	1
NB vs. WB
Nicotinate and nicotinamide metabolism	Niacinamide	0.00223	6.103	0.091	0.372
Glycerophospholipid metabolism	Choline	0.01781	4.027	0.365	0.020
Glycine, serine and threonine metabolism	Threonine and choline	0.03318	3.405	0.370	0.586
Arginine and proline metabolism	Arginine and aspartate	0.12315	2.094	0.579	0.269
Alanine, aspartate and glutamate metabolism	Aspartate	0.29566	1.218	0.754	0.553
β-Alanine metabolism	Aspartate	0.22422	1.495	0.733	0.521
Glutamine and glutamate metabolism	Glutamate	0.09918	2.310	0.822	1

¹Important metabolites are those represented in red box in the pathway analysis (Figures 3A–3C) as per its ID in KEGG pathway (accessible at http://www.genome.jp/kegg/pathway.html).