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. 2020 Nov 6;80(11):1093–1104. doi: 10.1055/a-1124-7225

Table 1  Examples of typical cytomorphological criteria for the identification of isolated tumour cells (based on 13 ).

Cell morphology/phenotype

  • Nuclear enlargement

  • Large nucleoli

  • Cell cluster

  • Cytoplasm with marked and/or irregular staining

  • Nucleus with irregular, granular structure

  • Cell size > size of haematopoietic cells

  • Nucleus partially covered by immunocytological staining

  • Cytokeratin filaments with mesh-like structure