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. Author manuscript; available in PMC: 2020 Nov 6.
Published in final edited form as: ACS Chem Neurosci. 2020 Jul 6;11(14):2058–2065. doi: 10.1021/acschemneuro.0c00316

Figure 1.

Figure 1

(Top) Sequences and the chemical modifications of the wt-, isoD7-, pS8-, and nY10-Aβ40 peptides. (Bottom Left) Sketches of reported Aβ40 fibril backbone structures with N-termini. The side chain orientations of D7 and S8/Y10 are highlighted in red and green respectively. The dashed rectangles show the inter- or intra-molecular packing that stabilize the fibril structures. (Bottom Right) Native-PAGE for the wt- and PTM-Aβ40 variants peptides.