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. 2020 Aug 8;99(11):6094–6118. doi: 10.1016/j.psj.2020.07.031

Figure 7.

Figure 7

Protein-protein interaction networks for DEGs overexpressed in the testis are involved in chromatin condensation, according to an analysis by the STRING online database, version 11.0. The line thickness indicates the strength of the data (tight lines indicate high scores >0.9; thin lines indicate medium scores >0.4). Red: condensed chromosome. Dark blue: protein serine/threonine kinase activity. Green: DNA metabolic process. Yellow: DNA conformation change. Light blue: catalytic activity, acting on DNA. Pink: DNA packing. Gene symbols: Bloom syndrome RecQ like helicase (BLM); bromodomain containing 4 (BRD4); BUB1 mitotic checkpoint serine/threonine kinase (BUB1); BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B); chromosome 14 open reading frame 39 (C14ofr39); DNA meiotic recombinase 1 (DMC1); DSN1 component of MIS12 kinetochore complex (DSN1); FK506 binding protein 6 (FKBP6); HORMA domain containing 1 (HORMAD1); kinesin associated protein 3 (KIFAP3); meiotic double-stranded break formation protein 4 (MEI4); non-SMC condensin I complex subunit D2 (NCAPD2); non-SMC condensin II complex subunit G2 (NCAPG2); NDC80 kinetochore complex component (NDC80); never in mitosis gene a-related kinase 2 (NEK2); polo like kinase 1 (PLK1); RAD21 cohesin complex component like 1 (RAD21L1); DNA repair protein RAD51 homolog (RAD51); RAD9 checkpoint clamp component B (RAD9B); ring finger protein 212 (RNF212); spindle and kinetochore associated complex subunit 2 (SKA2); spindle and kinetochore associated complex subunit 3 (SKA3); structural maintenance of chromosomes 1B (SMC1B); SPC25 component of NDC80 kinetochore complex (SPC25); synaptonemal complex protein 1 (SYCP1); testis expressed 11 (TEX11); DNA topoisomerase II alpha (TOP2A); DNA topoisomerase III beta (TOP3B).