Table 3.
Gene ontology analysis of differentially expressed genes (DEGs) identified in the epididymis and ductus deferens compared with those in the testis.
|
P value |
No DEGs |
Gene onthology |
P value |
No DEGs |
|---|---|---|---|---|
| Epididymis | Ductus deferens | |||
| Biological process | ||||
| Development, differentiation, and cell proliferation | ||||
| 2.717E-03 | 148 | Anatomical structure development | 1.902E-05 | 183 |
| 2.208E-02 | 93 | Animal organ development | ||
| 2.095E-03 | 43 | Animal organ morphogenesis | ||
| 5.369E-03 | 34 | Blood vessel development | 8.487E-03 | 38 |
| Cell differentiation | 1.748E-05 | 133 | ||
| 1.068E-02 | 64 | Cell population proliferation | 1.393E-06 | 86 |
| Cellular developmental process | 1.082E-05 | 140 | ||
| 8.588E-03 | 45 | Circulatory system development | 1.188E-02 | 51 |
| 4.266E-03 | 154 | Developmental process | 1.327E-06 | 196 |
| 1.403E-04 | 32 | Epithelial cell differentiation | 3.656E-04 | 35 |
| 5.215E-06 | 52 | Epithelium development | 2.954E-05 | 57 |
| 1.845E-02 | 12 | Formation of primary germ layer | 7.590E-04 | 15 |
| 8.345E-04 | 24 | Gland development | ||
| Multicellular organism development | 1.165E-02 | 156 | ||
| 1.527E-02 | 34 | Vasculature development | 2.577E-02 | 38 |
| 4.915E-07 | 76 | Tissue development | 4.564E-06 | 84 |
| 8.180E-05 | 49 | Tube development | 5.650E-05 | 56 |
| Morphogenesis | ||||
| 9.471E-03 | 45 | Anatomical structure formation involved in morphogenesis | 9.246E-05 | 57 |
| 1.564E-04 | 90 | Anatomical structure morphogenesis | 2.557E-07 | 113 |
| 2.089E-02 | 26 | Angiogenesis | 3.628E-03 | 31 |
| 1.375E-02 | 30 | Blood vessel morphogenesis | 3.255E-02 | 33 |
| 1.259E-03 | 15 | Branching morphogenesis of an epithelial tube | 2.596E-03 | 16 |
| Cell morphogenesis | 2.583E-05 | 53 | ||
| Cell morphogenesis involved in differentiation | 2.465E-04 | 40 | ||
| Cellular component morphogenesis | 1.810E-05 | 57 | ||
| Epithelial tube morphogenesis | 2.765E-02 | 22 | ||
| 8.967E-04 | 17 | Morphogenesis of a branching epithelium | 2.636E-03 | 18 |
| 5.797E-04 | 18 | Morphogenesis of a branching structure | 8.485E-03 | 18 |
| 5.131E-03 | 27 | Morphogenesis of an epithelium | 2.075E-02 | 29 |
| 2.069E-03 | 23 | Wound healing | ||
| 1.459E-03 | 32 | Tissue morphogenesis | 5.434E-04 | 37 |
| 5.905E-04 | 41 | Tube morphogenesis | 8.916E-04 | 46 |
| Apoptosis | ||||
| 3.437E-02 | 58 | Apoptotic process | ||
| 4.722E-03 | 7 | Apoptotic process involved in development | ||
| 1.130E-02 | 6 | Apoptotic process involved in morphogenesis | ||
| 3.909E-02 | 59 | Programmed cell death | ||
| 1.290E-02 | 52 | Regulation of apoptotic process | ||
| 1.177E-02 | 56 | Regulation of cell death | ||
| 1.103E-02 | 53 | Regulation of programmed cell death | ||
| Cell communication and respond to stimulus | ||||
| 2.481E-02 | 17 | Cell chemotaxis | ||
| Cell communication | 2.103E-03 | 206 | ||
| 4.590E-07 | 100 | Cellular response to chemical stimulus | 6.126E-05 | 108 |
| 4.733E-03 | 73 | Cellular response to organic substance | 1.074E-02 | 83 |
| Cellular response to stimulus | 1.920E-02 | 227 | ||
| Regulation of cell communication | 1.123E-04 | 131 | ||
| 2.155E-03 | 120 | Regulation of response to stimulus | 1.337E-05 | 149 |
| Negative regulation of cell communication | 7.280E-04 | 62 | ||
| 8.888E-03 | 58 | Negative regulation of response to stimulus | 8.958E-05 | 73 |
| 4.748E-02 | 67 | Positive regulation of response to stimulus | ||
| 2.061E-03 | 223 | Response to stimulus | 5.852E-03 | 261 |
| Cell motility | ||||
| Actin cytoskeleton organization | 4.425E-06 | 46 | ||
| Actin filament organization | 1.872E-03 | 28 | ||
| 3.340E-02 | 35 | Actin filament-based process | 1.664E-05 | 48 |
| 4.059E-02 | 50 | Cell migration | 3.402E-04 | 64 |
| 1.585E-02 | 9 | Cell migration involved in sprouting angiogenesis | ||
| Cell motility | 1.884E-03 | 66 | ||
| Locomotion | 3.707E-03 | 72 | ||
| Movement of cell or subcellular component | 4.228E-02 | 75 | ||
| 1.242E-02 | 26 | Positive regulation of cell migration | 1.629E-02 | 29 |
| Negative regulation of locomotion | 2.372E-02 | 21 | ||
| Regulation of cell migration | 6.945E-05 | 48 | ||
| Regulation of cell motility | 1.450E-04 | 49 | ||
| Regulation of locomotion | 1.184E-04 | 52 | ||
| 9.743E-03 | 28 | Positive regulation of locomotion | 6.284E-03 | 32 |
| 1.330E-02 | 10 | Actin polymerization/depolymerization | ||
| 2.782E-02 | 26 | Positive regulation of cell motility | 1.432E-02 | 30 |
| Adhesion | ||||
| Cell-cell adhesion | 5.274E-03 | 37 | ||
| Cell-matrix adhesion | 2.133E-02 | 18 | ||
| 5.491E-04 | 24 | Cell-substrate adhesion | 4.543E-03 | 25 |
| Negative regulation of cell adhesion | 2.706E-04 | 20 | ||
| 1.125E-02 | 30 | Regulation of cell adhesion | 1.820E-05 | 40 |
| 3.549E-05 | 54 | Biological adhesion | 1.738E-07 | 67 |
| 2.798E-05 | 54 | Cell adhesion | 1.281E-07 | 67 |
| Oxidative stress | ||||
| 3.655E-02 | 16 | Reactive oxygen species metabolic process | ||
| 8.575E-04 | 49 | Response to oxygen-containing compound | 3.930E-02 | 49 |
| 2.880E-02 | 96 | Response to stress | ||
| 1.320E-02 | 9 | Positive regulation of oxygen species | ||
| Other | ||||
| 4.913E-03 | 31 | Transmembrane receptor protein tyrosine kinase signaling pathway | ||
| 2.278E-02 | 24 | Regulation of hormone levels | ||
| Cellular component | ||||
| Cell part | ||||
| 1.544E-08 | 27 | Apical part of cell | 4.019E-04 | 23 |
| 5.237E-05 | 32 | Cell surface | 2.662E-02 | 30 |
| 7.274E-05 | 66 | Extracellular region | ||
| 1.544E-04 | 51 | Extracellular region part | 5.767E-03 | 54 |
| 9.221E-06 | 43 | Extracellular space | 1.149E-02 | 41 |
| 4.052E-02 | 52 | Vesicle | ||
| Cytoplasm | 1.236E-02 | 308 | ||
| Endoplasmic reticulum | 3.518E-05 | 67 | ||
| Membrane | ||||
| 4.969E-07 | 21 | Apical plasma membrane | 2.515E-02 | 16 |
| 3.425E-02 | 14 | Cell projection membrane | ||
| Endomembrane system | 5.972E-03 | 127 | ||
| 7.276E-03 | 250 | Membrane | 1.644E-03 | 303 |
| 2.620E-02 | 206 | Membrane part | ||
| 5.671E-07 | 131 | Plasma membrane | 1.837E-07 | 155 |
| 1.604E-05 | 75 | Plasma membrane part | 1.255E-04 | 84 |
| 3.548E-04 | 37 | Plasma membrane region | 6.810E-03 | 39 |
| 2.656E-02 | 18 | Side of membrane | ||
| Junction | ||||
| 1.853E-03 | 19 | Adherens junction | 7.537E-07 | 27 |
| 4.196E-03 | 19 | Anchoring junction | 6.057E-07 | 28 |
| 2.609E-02 | 33 | Cell junction | 1.009E-05 | 47 |
| Cell-cell junction | 6.441E-04 | 28 | ||
| 1.103E-07 | 137 | Cell periphery | 3.261E-08 | 162 |
| 2.538E-02 | 13 | Cell-substrate adherens junction | 6.923E-06 | 20 |
| 4.005E-02 | 13 | Cell-substrate junction | 2.807E-06 | 21 |
| Cell movement | ||||
| 4.531E-02 | 24 | Actin cytoskeleton | 7.409E-06 | 36 |
| Actin filament bundle | 2.414E-03 | 10 | ||
| Actomyosin | 4.166E-03 | 10 | ||
| 2.921E-03 | 13 | Cluster of actin-based cell projections | 2.781E-02 | 13 |
| Contractile actin filament bundle | 9.785E-04 | 10 | ||
| 1.767E-02 | 13 | Contractile fiber | 1.052E-02 | 15 |
| 1.653E-02 | 12 | Contractile fiber part | 7.428E-03 | 14 |
| 3.204E-03 | 10 | I band | 3.510E-03 | 11 |
| 1.060E-02 | 13 | Myofibril | 5.845E-03 | 15 |
| Sarcolemma | 5.392E-03 | 10 | ||
| 8.075E-03 | 12 | Sarcomere | 3.208E-03 | 14 |
| Stress fiber | 9.785E-04 | 10 | ||
| 4.838E-03 | 9 | Z disc | 5.470E-04 | 11 |
| Molecular function | ||||
| Protein binding | 2.490E-06 | 238 | ||
| Enzyme binding | 1.890E-02 | 85 | ||
| Cytoskeletal protein binding | 3.340E-03 | 51 | ||
| Protein-containing complex binding | 7.662E-04 | 48 | ||
| 3.559E-04 | 40 | Calcium ion binding | ||
| Protein phosphorylation | 5.390E-03 | 26 | ||
| 4.321E-02 | 37 | Protein-containing complex binding | ||
| Actin binding | 9.651E-04 | 31 | ||
| Actin filament binding | 3.261E-02 | 15 | ||
| 9.534E-03 | 13 | Glycosaminoglycan binding | ||
| 2.321E-02 | 13 | Sulfur compound binding | ||
| 4.189E-03 | 11 | Heparin binding | ||
| Extracellular matrix binding | 2.588E-02 | 7 | ||
| S100 protein binding | 2.216E-03 | 6 | ||
| 1.518E-02 | 4 | Bicarbonate transmembrane transporter activity | ||