Table 1.
Genes of researched signatures.
| Gene signature | Gene | Source |
|---|---|---|
| ECM-receptor interaction | GP1BA, COL6A2, COL6A3, GP1BB, COL5A2, COL6A1, LAMA1, VWF, HSPG2, TNN, FN1, ITGA9, GP9, COMP, IBSP, CD36, CHAD, GP5, VTN, THBS4, ITGA4, ITGA3, ITGA2B, ITGA7, ITGA5, COL5A1, COL4A6, ITGA11, SV2C, COL2A1, COL3A1, COL4A1, AGRN, COL4A2, COL4A4, ITGB3, ITGB4, RELN, ITGB5, ITGB6, ITGB7, LAMC2, ITGAV, ITGB1, LAMB2, SPP1, LAMB3, LAMC1, COL1A1, LAMA4, LAMA5, LAMB1, COL1A2, ITGA10, GP6, ITGA8, LAMB4, TNR, CD47, SV2A, CD44, DAG1, TNXB, LAMA3, LAMA2, SDC3, ITGB8, ITGA6, ITGA2, ITGA1, SV2B, TNC, COL11A1, LAMC3, COL11A2, HMMR, SDC2, SDC4, COL5A3, THBS3, COL6A6, THBS2, SDC1, THBS1 | KEGG hsa04512 |
| Cell adhesion molecules (CAMs) | CDH5, JAM3, CDH3, NLGN3, CDH4, CD80, NLGN1, CD86, CD28, CD274, PDCD1LG2, ITGA9, ITGAL, NRCAM, ITGAM, CD34, CD276, ICOSLG, CADM3, ITGA4, ICOS, SIGLEC1, CADM1, HLA-G, CLDN20, PECAM1, CD22, ITGB7, SELL, VCAM1, ITGAV, SELP, SPN, ITGB1, SELPLG, ITGB2, CDH2, JAM2, CTLA4, HLA-DRB4, CDH15, CLDN18, CD4, HLA-DRB5, CNTN1, NLGN2, HLA-DRB3, NRXN3, ALCAM, SELE, CD8A, CD8B, CD6, NLGN4X, CLDN17, L1CAM, ITGB8, MAG, VCAN, HLA-F, NFASC, HLA-E, NRXN1, HLA-DPA1, HLA-DPB1, CLDN9, GLG1, HLA-DQA1, HLA-DQA2, HLA-DQB1, NRXN2, CD2, CLDN16, CLDN23, MADCAM1, SDC2, SDC4, CLDN14, CD40, SDC1, OCLN, PVR, HLA-DRB1, NECTIN2, CDH1, HLA-DRA, NECTIN1, HLA-DOA, HLA-DOB, CLDN10, CNTNAP1, ICAM2, ICAM3, CLDN8, CLDN2, CLDN6, CLDN5, CLDN1, ICAM1, NEO1, HLA-C, HLA-B, ESAM, CD40LG, PTPRM, HLA-DMB, HLA-DMA, HLA-A, F11R, PDCD1, CLDN19, PTPRF, CLDN15, CD226, CD99, CLDN22, CNTN2, ITGA6, CNTNAP2, MPZ, MPZL1, PTPRC, NECTIN3, ITGA8, NCAM2, NCAM1, CD58, NEGR1, CLDN11, SDC3, CLDN3, CLDN7, CLDN4 | KEGG hsa04514 |
| Complement and coagulation cascades | F2, F2R, VWF, KNG1, FGB, PLAT, SERPIND1, MBL2, F3, F5, SERPINA1, PLAUR, F7, PLAU, F10, F9, C1S, TFPI, F8, KLKB1, CR2, MASP1, C9, A2M, CR1, F12, F13A1, F11, CFI, SERPING1, MASP2, THBD, C1QC, C8A, F13B, C7, C8G, C8B, CD59, SERPINA5, FGG, CD55, C6, C5AR1, C5, BDKRB1, CFD, C1QA, C1R, C4BPB, C4BPA, C4B, C4A, BDKRB2, CFH, CFB, CPB2, CD46, PROS1, SERPINF2, PROC, C3, C1QB, C3AR1, FGA, SERPINE1, PLG, C2, SERPINC1 | KEGG hsa04610 |
| TGF-beta signaling pathway | TFDP1, NOG, TNF, GDF7, INHBB, INHBC, COMP, INHBA, THBS4, RHOA, CREBBP, ROCK1, INHBE, THBS2, DCN, ID1, ID2, RPS6KB1, RPS6KB2, CUL1, ID4, SMAD3, MAPK3, RBL2, SMAD4, RBL1, NODAL, THBS1, THBS3, SP1, SMAD1, MYC, SMAD2, MAPK1, SMURF2, SMURF1, EP300, BMP8A, GDF5, SKP1, CHRD, ZFYVE16, BMP6, BMP5, E2F4, TGFB2, TGFB1, IFNG, CDKN2B, PPP2CB, PPP2CA, PPP2R1A, ID3, SMAD5, RBX1, FST, PITX2, ZFYVE9, BMP7, PPP2R1B, TGFBR2, AMHR2, LTBP1, LEFTY1, AMH, TGFBR1, SMAD9, LEFTY2, SMAD7, ROCK2, BMP8B, ACVR1C, TGFB3, SMAD6, BMPR2, GDF6, BMPR1A, BMPR1B, ACVRL1, ACVR2B, ACVR2A, ACVR1, BMP4, E2F5, BMP2 | KEGG hsa04530 |
| Base excision repair | NEIL2, MPG, SMUG1, XRCC1, POLE4, HMGB1, POLE3, POLD4, MBD4, OGG1, UNG, POLD3, MUTYH, PARP1, LIG1, PCNA, NEIL1, POLE2, PARP4, PARP3, PARP2, POLB, APEX1, POLL, POLD1, POLD2, POLE, NEIL3, FEN1, TDG, APEX2, LIG3, HMGB1P1, NTHL1, HMGB1P40 | KEGG hsa03410 |
| DNA replication | DNA2, POLE4, POLE3, PRIM1, PRIM2, POLD4, RFC4, RFC5, RPA1, POLA1, RPA3, POLD3, LIG1, SSBP1, FEN1, RNASEH2B, RPA2, PCNA, RPA4, RNASEH1, RNASEH2C, MCM4, POLE2, MCM3, MCM6, MCM5, POLA2, FEN1, MCM2, MCM7, POLD1, POLD2, RNASEH2A, POLE, RFC1, RFC3, RFC2 | KEGG hsa03030 |
| Nucleotide excision repair | MNAT1, POLE4, ERCC4, POLE3, ERCC3, ERCC6, ERCC5, GTF2H5, POLD4, ERCC2, RFC4, CETN2, RFC5, GTF2H3, RPA1, RAD23B, RBX1, DDB2, RPA3, POLD3, RPA2, RAD23A, PCNA, RPA4, DDB1, POLE2, ERCC1, POLD1, GTF2H4, POLD2, POLE, RFC1, RFC3, RFC2, XPC, XPA, GTF2H2, GTF2H1, CDK7, LIG1, CUL4A, CUL4B, ERCC8,CCNH | KEGG hsa03420 |
| Mismatch repair | MLH3, POLD1, MLH1, POLD2, RFC1, MSH2, RFC3, RFC2, MSH3, POLD4, PMS2, RFC4, LIG1, SSBP1, RPA4, EXO1, RFC5, RPA1, MSH6, RPA3, POLD3, RPA2, PCNA | KEGG hsa03430 |