Table 4.

Micro-CT outcome parameters interpretation.

Parameters	Introduction
Tissue volume (TV)	The volume of the volume-of-interest (VOI), including pores and cavity inside the bone
Bone volume (BV)	The volume of binarized objects (mineralized bones) within the VOI
Bone mineral density (BMD)	BMD is defined as the volumetric density of calcium hydroxyapatite (CaHA) in biological tissue regarding g.cm-3. It is calibrated using phantoms with a known density of CaHA. In the present study, BMD relates to the amount of bone within a mixed bone-soft tissue region
Bone mineral content (BMC)	BMC is calculated by using BMD∗TV
Pore number (PN)	The total number of closed pores within cortical bone
Closed pore volume (CPV)	Closed pores in 3D is a connected assemblage of space and surrounded on all slides in 3D by solid voxels. CPV is the volume of closed pores.
Closed porosity (CPP)	The volume of pores as a percentage of total cortical tissue volume
Total pore volume (TPV)	The total volume of pores within VOI of cortical bone
Trabecular connectivity	Developed and defined by Hahn et al. (1992). It is a 3D calculation based on a 2D scale. In brief, a higher number means better connected trabecular structure.