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. 2020 Oct 23;9(10):e14322. doi: 10.2196/14322

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©Bárbara De Barros Gonze, Ricardo Da Costa Padovani, Maria Do Socorro Simoes, Vinicius Lauria, Neli Leite Proença, Evandro Fornias Sperandio, Thatiane Lopes Valentim Di Paschoale Ostolin, Grace Angélica De Oliveira Gomes, Paula Costa Castro, Marcello Romiti, Antonio Gagliardi, Rodolfo Leite Arantes, Victor Zuniga Dourado. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 23.10.2020.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.

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The sequential multiple assignment randomized trial (SMART) design applied in this study. Letters at the end of the flowchart indicate the way of the intervention. A: app only during 24 weeks; B: app only during 12 weeks and app + tailored messages in the last 12 weeks; C: app only during 12 weeks and app + tailored messages + gamification in the last 12 weeks; D: app + tailored messages during 24 weeks; E: app + tailored messages during 12 weeks and app only in the last 12 weeks; F: app + tailored messages during 12 weeks and app + tailored messages + gamification in the last 12 weeks; R: randomization and rerandomization.