Figure 7.

Inhibition of NIK Activity by Small Molecule B022 Ameliorates STZ-Induced Diabetes In Vivo

C57BL6 WT mice were intraperitoneally injected with a high dose of STZ (200 mg/kg) to induce diabetes, and then B022 or vehicles were injected via tail vein four times per day. (A) Experiment schedule. (B) Blood glucose (n = 10 for each group). (C) Glucose tolerance test (GTT) (n = 10 for each group). (D) Insulin tolerance test (ITT) (n = 7 for each group). (E) Serum insulin levels (n = 10 for each group). (F) Pancreas insulin contents (n = 10 for each group). (G) Representative islets from B022- and vehicle-treated mice were immunostained with insulin. The scale bar represents 100 μm. (H) Relative insulin-positive areas of B022- and vehicle-treated mice (n = 6–7 for each group). ∗p < 0.05, ∗∗p < 0.01. Data represent the mean ± SEM.