. Author manuscript; available in PMC: 2022 Feb 1.

Published in final edited form as: Drug Deliv Transl Res. 2021 Feb;11(1):182–191. doi: 10.1007/s13346-020-00758-9

Table 1:

Pharmacokinetics of PD98059 following IV injection.

Non-compartmental analysis (NCA)			1-Compartment model			2-Compartment model
Parameter	Unit	Value	Parameter	Unit	Value	Parameter	Unit	Value
K	min⁻¹	0.0074	C₀	ng/ml	3433.44	A	ng/ml	3236.5
T_1/2	min	93.93	K	min⁻¹	0.045	α	min	0.104
C₀	ng/ml	3863.5	T_1/2	min	15.5	B	ng/ml	980.76
AUC_0-t	ng.min/ml	142723.37	V	ml	291.25	β	min	0.0094
AUC_0-inf	ng.min/ml	152980.9	CI	ml/min	13.03	K₁₀	min⁻¹	0.031
AUMC_0-inf	ng.min²/ml	14922241.77	AUC_0-t	ng.min/ml	76774.82	K₁₂	min⁻¹	0.05
MRT_0-inf	min	97.54	AUC_0-inf	ng.min/ml	76774.83	K₂₁	min⁻¹	0.031
V	ml	885.82	AUMC	ng.min²/ml	1716754	T_1/2α	min	6.7
CI	ml/min	6.54	MRT	min	22.36	T_1/2β	min	73.36
V_ss	ml	637.62	V_ss	ml	291.25	C₀	ng/ml	4217.23
			R²		0.9807	V	ml	237.12
						CI	ml/min	7.4
						AUC_0-t	ng.min/ml	131605.22
						AUC_0-inf	ng.min/ml	135064
						AUMC	ng.min²/ml	11287504.55
						MRT	min	83.57
						V_ss	ml	618.76
						R²		0.999

K Elimination rate constant, T_1/2 Plasma half-life, C₀ Plasma concentration at 0 time., AUC Area under the plasma concentration-time curve, AUMC Area under the moment curve, MRT Mean residence time, V Volume of distribution, Cl Clearance, V_ss Steady state volume of distribution