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. Author manuscript; available in PMC: 2021 Feb 7.
Published in final edited form as: Leukemia. 2020 May 7;35(2):377–388. doi: 10.1038/s41375-020-0845-6

Figure 4. SHIN2 and methotrexate synergize in Molt4 cells.

Figure 4.

(a-b) Growth of Molt4 cells incubated with increasing concentrations of (+)SHIN2 in the presence of 0, 20, 30 and 40 nM methotrexate (MTX) normalized to DMSO control proliferation (a) or to proliferation for the same methotrexate dose in the absence of (+)SHIN2 (b) (n=3). (c) Isobologram for (+)SHIN2 and methotrexate showing the combinations of the drug that achieve a decrease in proliferation of > 50%; purple, actual values; black line, theoretical additive effect.