FIGURE 4.

Intranodal pressure (INP) reflects the antitumor effects of cis‐dichlorodiammineplatinum(II) (CDDP) given with a lymphatic drug delivery system. A, Temporal changes in INP for subiliac lymph nodes (SiLNs) inoculated with KM‐Luc/GFP cells. The INP of the non‐cancerous SiLN was approximately 0 mm Hg on day 0. INP increased progressively in SiLNs inoculated with KM‐Luc/GFP cells and injected with saline as a control for CDDP (day 3, n = 8; day 6, n = 7). However, CDDP treatment (KM‐Luc/GFP + CDDP) slightly reduced the INP between day 3 (n = 5) and day 6 (n = 13), and the value on day 6 was significantly lower than that of the KM‐Luc/GFP + saline group on day 6. B, Temporal changes in INP for SiLNs inoculated with FM3A‐Luc cells. The INP of the control group (FM3A‐Luc + saline) showed a substantial elevation on day 7 (n = 4) followed by a decrease on day 14 (n = 7). Treatment with CDDP (FM3A‐Luc + CDDP) resulted in significant decreases in INP on day 7 (n = 5) and day 14 (n = 8). Error bars indicate SD. *P < .05, **P < .01