Clinical specimens verified the control axis and immune infiltration. Based on the expression values of CD3, CD8, IFN‐γ, and GZMB, Clinical samples we screened were defined as hot and cold tumor. Hot group exhibited high expression of the 4 genes (Four Genes High). Cold group exhibited low expression of the 4 genes (Four Genes Low). A, RP11‐1094M14.8 was highly expressed in high immune infiltration GC. B, miR‐1269a exhibited low expression in high immune infiltration GC. C, CXCL9 was highly expressed in high immune infiltration GC (***P < .0001, **P < .001). D, Immuno‐correlation analysis of CXCL9 and RP11‐1094M14.8. Based on the expression values of CXCL9, the clinical specimens were divided into 2 groups. E, F, Immunohistochemical analysis was performed to evaluate the correlation between CD8 and CXCL9 protein expression. G, Kaplan–Meier curve of CXCL9 that significantly correlated with overall survival