Figure 2.

Tumor incidence and size of htgUGT1A mice 40 wk after chemical induction of hepatocarcinogenesis. Total number (A) and total accumulated diameter (B) of all visible tumors detected at the liver surface of htgUGT1A–wild‐type (WT) and single‐nucleotide polymorphism (SNP) mice. In the absence of UGT1A polymorphisms, less tumors with a reduced cumulative diameter were detected after diethylnitrosamine (DEN) and DEN + coffee cotreatment. C, Percentage proportion of mice bearing tumors bigger than 5 mm. The proportion of mice with especially large tumors was higher in htgUGT1A‐SNP mice. D, Liver/body ratio after DEN and DEN + coffee cotreatment. The relative liver weight was significantly higher in htgUGT1A‐SNP mice after DEN‐treatment, whereas a comparable ratio was observed in DEN + coffee‐cotreated mice. Groups without the same letter are significantly different; P < 0.05 was considered statistically significant