Figure 3.

Aminotransferase activity level of htgUGT1A mice 40 wk after chemical induction of hepatocarcinogenesis. Liver injury was assessed by serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities. Mice carrying the Gilbert syndrome–associated single‐nucleotide polymorphism (SNP) haplotype had significantly higher AST and ALT levels. Each column represents the mean ± standard deviation. Groups without the same letter are significantly different; P < 0.05 was considered statistically significant. DEN, diethylnitrosamine; WT, wild‐type