TABLE 3.

Somatic mutations detected in the 7 ACD‐associated RCCs

Sample ID	Gene symbol	Type	Coverage	Variant frequencies (%)	Nucleotide change	Amino acid change	Pathogenicity
ACD‐RCC1	None
ACD‐RCC2	RRM1	SNV	683	30.5	c.1320+48C>T
	LRP1B	SNV	1139	25.6	c.82+55G>A
ACD‐RCC3	SYNE1	SNV	635	25.7	c.20112G>T	p.Gln6704His	No information
	MTOR	Deletion	266	24.4	c.6000delG	p.Glu2000fs	Pathogenic
ACD‐RCC4	BRD3	SNV	365	40.5	c.381A>G
ACD‐RCC5	SF3B1	SNV	559	36.1	c.3013+30T>C
	ERBB2	SNV	629	21.6	c.2844C>T
	RHOH	SNV	472	21.6	c.27G>T	p.Leu9Phe	No information
	PRKDC	SNV	559	19.9	c.4216T>C	p.Leu1405Pro, p.*1406Gln	No information
	MAGI1	SNV	567	19.0	c.*693A>G
	EPHA7	SNV	719	18.8	c.1299T>C
	NTRK3	SNV	1347	17.2	c.2066C>T	p.Ala689Val	No information
	GRM8	SNV	645	15.8	c.2678G>A	p.Ser893Asn	No information
	RALGDS	SNV	484	14.0	c.1585C>T	p.Arg474Trp, p.Arg529Trp	No information
	FANCA	SNV	574	12.0	c.187G>A	p.Glu63Lys	No information
ACD‐RCC6	TCF3	Insertion	451	73.8	c.1167+29_1167+30insCA
	FGFR3	SNV	507	35.9	c.2169‐18T>C
	NLRP1	SNV	53	11.3	c.186G>T
ACD‐RCC7	TCF3	Insertion	169	80.5	c.1167+29_1167+30insCA
	ARID2	SNV	2200	38.9	c.2582T>G	p.Ile861Ser	No information
	COL1A1	SNV	1150	36.6	c.2288G>A	p.Arg763His	Pathogenic
	CSMD3	SNV	1906	36.4	c.2409T>C
	ATR	Deletion	164	15.2	c.3172‐27_3172‐24delATTT